Modernizing Pharmaceutical Manufacturing: from Batch to Continuous Production

Emerging Technology as a Key Enabler for Modernizing Pharmaceutical Manufacturing.

Optimization of Single Cell Protein Production from Cheese Whey Under Batch and Continuous Cultivation

In this research the microorganism was initially isolated and selected after evaluation based on COD reduction of cheese whey and biomass production. The selected microorganism was identified as Trichosporon sp. The cultivation conditions of the microorganism were optimized under batch: temperature 30˚C initial pH = 6 aeration speed = 2 ν.ν.m and agitation rate: 800 rpm. Under these conditions,...

Optimization of Single Cell Protein Production from Cheese Whey Under Batch and Continuous Cultivation

In this research the microorganism was initially isolated and selected after evaluation based on COD reduction of cheese whey and biomass production. The selected microorganism was identified as Trichosporon sp. The cultivation conditions of the microorganism were optimized under batch: temperature 30˚C initial pH = 6 aeration speed = 2 ν.ν.m and agitation rate: 800 rpm. Under these conditions,...

Performance of Biological hydrogen Production Process from Synthesis Gas, Mass Transfer in Batch and Continuous Bioreactors

Biological hydrogen production by anaerobic bacterium, Rhodospirillum rubrum was studied in batch and continuous bioreactors using synthesis gas (CO) as substrate. The systems were operated at ambient temperature and pressure. Correlations available in the literature were used to estimate the gas-liquid mass transfer coefficients (KLa) in batch reactor. Based on experimental results for the con...

Control Systems Engineering in Continuous Pharmaceutical Manufacturing May 20-21, 2014 Continuous Manufacturing Symposium.

This white paper provides a perspective of the challenges, research needs, and future directions for control systems engineering in continuous pharmaceutical processing. The main motivation for writing this paper is to facilitate the development and deployment of control systems technologies so as to ensure quality of the drug product. Although the main focus is on small-molecule pharmaceutical...